AAALAC International overlays these standards on the laws and regulations for the country in which the institution seeking accreditation is located and uses other specialty publications to supplement information about specific procedures or techniques related to the care and use of laboratory animals, designated as reference resources (http://www.aaalac.org/accreditation/resources.cfm). The LAC in the U.K. also acted as a clearing house for information on all aspects of laboratory animal science. Presentation Summary : Preliminary Industry Survey Results. It was edited initially by M. F. W. Festing with assistance of J. C. Howard (alloantigen news) and Roy Robinson (mutant lists), and was distributed internationally. pharmacology and toxicology. A regular scientific conference has also been organized by PALAS yearly to bring together people in various disciplines for the purpose of scientific presentation of new research data and information dissemination on animal welfare and serve as an avenue for networking and collaboration. They are smallest, cheap and easy to handle. 6. Kathryn Bayne, ... Virginia Williams, in Laboratory Animal Welfare, 2013. Find specific details on this topic and related topics from the Merck Vet Manual. Experimental pharmacology deals with effects of various test substances studied on different animal species which is aimed at finding out safe therapeutic agent suitable for public health as well as mechanism and site of action of a test substance. Regional Chapter Presidents’ Meeting PPT. Additional IACUC and animal program-related links and Web resources also are listed as references. The researcher creates a flow diagram of their experimental set-up grouped in three domains: the experiment (general questions on hypotheses and aims, animals used, animal strains, etc. The Safety Pharmacology Society recognizes that scientific and medical knowledge developed through animal research has saved countless lives, has improved human and animal health, and has alleviated pain and suffering. and the analysis stage (e.g. (89 month(s) ago), i like ur presentation plzz send it me at rekha03september86@gmail.com, By: Pharmacology Practical is created specially for the Diploma, Under graduate and Post graduate students of Pharmacy. AAALAC International is a private, nonprofit organization that promotes the humane treatment of animals in science. To ensure that the needle is in the vein, aspirate to get blood into the syringe .PowerPoint Presentation: After ensuring that the needle is properly placed, inject the fluid steadily into the veinPowerPoint Presentation: GUINEA PIG Equipment : 27-30G,1inch needle Volume : 0.5ml Sites : lateral saphenous, cephalic vein, marginal ear veinINTRAPERITONEAL(i.p): INTRAPERITONEAL (i.p) Most frequently used parenteral routes in rodents Lower left quadrant of abdomen Aspirate prior to injection Yellow fluid : needle could be in bladder Greenish fluid : needle could be in intestine Blood : may have entered blood vesselMOUSE: MOUSE Equipment : 23-27G,1/2 to 1-inch needle Volume : not to exceed 2ml Site : lateral aspect of lower left quadrant of abdomenRAT: RAT Equipment : 20-25G,1-1.5 inch needle Volume : not to exceed 10ml Site : lower quadrant of abdomenPowerPoint Presentation: RABBIT E quipment : 19-20G needle, syringe, restraining board Volume : 50-100ml Site : lower abdominal quadrant Chemical restraint with ketamine GUINEA PIG E quipment : 19-22G needle with syringe, restraining board Volume : 10-15ml Site : lower abdominal quadrant Light anesthesiaSUBCUTANEOUS(sc): SUBCUTANEOUS (sc) Equipment : syringe & 25-27G, 1/2 to 3/4inch needle Volume : not to exceed 2-3ml Site : loose skin between the shoulder blades MOUSEPowerPoint Presentation: RAT Equipment : 20-25G needle, syringe Volume : not to exceed 10ml Site : loose skin between shoulder bladePowerPoint Presentation: injected in the scruff of the neck with a minimum of immobilizationPowerPoint Presentation: RABBIT Equipment : 20-23G,1 inch needle, syringe Volume : 30-50 ml Sites : between the scapulaePowerPoint Presentation: To give the subcutaneous injection begin by lifting up the skin.PowerPoint Presentation: Choose a place where the skin is very loose, for example over the shoulder blades.PowerPoint Presentation: Aspirate before injecting in order to ensure that you have not entered a blood vessel.PowerPoint Presentation: If no blood is seen after aspirating, inject the fluid under the skinPowerPoint Presentation: GUINEA PIG E quipment : 20-22G,3/4-1 inch needle, Short , heavy gauge needlesINTRAMUSCULAR(im): INTRAMUSCULAR (im) MOUSE Equipment : syringe & 26-30G, 1/2-inch needle Volume : not to exceed 0.05ml Sites : back &hind leg muscles Not recommended Volume injected limitedPowerPoint Presentation: RAT Equipment : <21G , ½ inch needle & syringe Volume : not to exceed 0.3ml Sites : back &hind leg musclesPowerPoint Presentation: Equipment : 22-23G,1 inch needle, syringe Volume : 0.5ml Sites : back muscles lateral to the vertebrae & caudal to ribs or lateral thigh muscles RABBITPowerPoint Presentation: GUINEA PIG Equipment : 20-22G , 1 inch needle, syringe Volume : 0.3ml Sites : lower back (lumbar) muscles & caudal muscles of thigh & quadricepsBLOOD COLLECTION TECHNIQUES: BLOOD COLLECTION TECHNIQUES 10-15% of total blood volume or 1% of body weight is the maximum amount of blood that should be collected at one time maximum amount of blood be withdrawn only once every two weeks .05% of B.W is the amount withdrawn in multiple samplingPowerPoint Presentation: Site preparation Area of injection cleaned with alcohol Some procedures requires anesthesia Veins dilation accomplished Total blood volume Mouse : 70-80ml/kg Rat : 50-65ml/kg Rabbit : 45-70ml/kg Guinea pig : 65-90ml/kgPowerPoint Presentation: MOUSE TAIL VEIN VENIPUNCTURE For collection of small amount of blood (0.1 ml ) Lateral or dorsal veins used Gentle aspiration to avoid collapse of vesselTools for Blood Collection by amputation of tail tip : Tools for Blood Collection by amputation of tail tip alcohol cotton ball mouse restrainer Scissors Pipetteman and tips A vial for blood collectionPowerPoint Presentation: Place mouse on a cage lid and grasp the loose skin behind the ears by the thumb and forefingerPowerPoint Presentation: Push the mouse into the restrainerPowerPoint Presentation: Leave the tail of the mouse outside the cover of the restrainerPowerPoint Presentation: Amputate the tip of the mouse tail by scissorsPowerPoint Presentation: Massage the tail and collect blood by pipettemanPowerPoint Presentation: Equipment restraining tube, scalpel blade, 27-gauge syringe needle, blood collection tube and cotton wool . adel383683 In select cases, a veterinarian may dispense small amounts of controlled substances for anesthesia, analgesia, or euthanasia to individual researchers, but these processes must mimic state regulations for dispensing (e.g., veterinary practitioner clinic dispensing to clients), including prescription directions and maintaining dispensing records.   Under the section on veterinary medical care, surgical activities, assessment of animal pain and distress, use of analgesia and anesthesia, euthanasia methods, and drug storage and control are described in detail. Objective: To evaluate pharmacy students' perceptions, barriers, and confidence regarding animal use in the pharmacology laboratory course, and the effect of animal handling on their confidence. Experimental Pharmacology, Volume 2 . Most controlled substances used in laboratory animals are for anesthesia, analgesia, and euthanasia purposes. Used in Experimental Pharmacology: It also gave the first national listing of animal suppliers and users. In 1996, the name was changed to underscore that AAALAC International accredits institutional animal care and use programs around the world. In order to view it, please AAALAC International has a cooperation agreement with the World Organisation for Animal Health (OIE) to use Chapter 7.8 of the OIE's Terrestrial Animal Health Code (OIE, 2011; http://web.oie.int/eng/normes/mcode/en_chapitre_1.7.8.htm), “Use of Animals in Research and Education” (an AAALAC International reference resource) in its assessments of programs worldwide, with particular emphasis on countries that do not have their own legislative framework for ensuring the welfare of animals used in research, testing, or teaching. Commonly used laboratory animals in experimental – pharmacology 4. Displaying experimental animals in pharmacology PowerPoint Presentations. Copy, Automatically changes to Flash or non-Flash embed, WordPress Embed Various government and nongovernment organizations strongly oppose the use of animal experimentation for teaching purposes. S.K.Kulkarni, 3 rd Edn; Pg: 12-14. In addition, many laboratory animal veterinarians maintain active practitioner licenses and possess active DEA registrations. Introduction to experimental pharmacology. The ... pharmacology and toxicology. Blood Collection From Saphenous VeinPowerPoint Presentation: The mouse is restrained in a plastic tube with air holes in the end.PowerPoint Presentation: Shaving Avoid cutting the skin by holding the blade as flat as possible.PowerPoint Presentation: The vein is now easily visible.PowerPoint Presentation: vein punctured with a 27-gauge needle held at approximately 90 degrees to the skin.PowerPoint Presentation: Bleeding Immediately after puncture a drop of blood will appearPowerPoint Presentation: Blood collection blood collected in a sampling tube or microhaematocrit tube 100 microliters can be collectedPowerPoint Presentation: TOE CLIPPING/ TAIL CLIPPING Unacceptable method CARDIAC PUNCTURE Equipment : 0.9-0.5mm needle Terminal blood collection Requires anesthesia Withdraw blood slowly Upto 1ml recoveredPowerPoint Presentation: ORBITAL SINUS VENIPUNCTURE Equipment : capillary tubes Convenient & easy method Upto 0.5ml can be recovered Tube directed into orbital sinus Inserted into medial canthus of eye Requires anesthesiaPowerPoint Presentation: Use a sharp end glass capillary tube to penetrate the orbital conjunctiva and rupture the orbital sinusPowerPoint Presentation: Collect blood with a vialPowerPoint Presentation: AXILLARY BLEED Equipment : scalpel blade,3-5cc syringe Blood recovered from axillary region in a terminal exsanguination Requires anesthesia 1-2ml of blood recoveredPowerPoint Presentation: RAT Lateral tail vein venipuncture : method same as in mice Ventral tail artery Equipment : 22G needle,3cc syringe Anesthesia required Cardiac puncture : same as in mice Orbital sinus venipuncture : same as in micePowerPoint Presentation: RABBIT MARGINAL EAR VEIN: Equipment : butterfly set Small vol of blood collected Sedation & vasodilation with acepromazinePowerPoint Presentation: CENTRAL EAR ARTERY Equipment : plain 20G, 1 inch needle attached to silicone coated tube Volume : 10ml/kg body wt Sedation & vasodilatation with acepromazinePowerPoint Presentation: CARDIAC PUNCTURE Equipment : 18G, 1.5 inch needle attached to vacuum tube Terminal blood collection Requires anesthesiaPowerPoint Presentation: GUINEA PIG LATERAL SAPHENOUS VEIN VENIPUNCTURE Equipment : 22G needle/ scalpel blade Small vol blood collected LATERAL SAPHENOUS VEIN(VACUUM ASSISTED) Larger vol blood collected META TARSAL VEIN TOE CLIPPING Unacceptable methodPowerPoint Presentation: CRANIAL VENACAVA Equipment : 22-23G needle,3-6 cc syringe Site : manubrium of sternum Repetitive collection of >1ml blood (upto 7ml/kg) Anesthesia required CARDIAC PUNCTURE Equipment : 20-22G needle,12-20cc syringe Not recommended as a repetitive blood sampling procedure Requires anesthesiaCONCLUSION: CONCLUSIONREFERENCES : REFERENCES Fundamentals of Experimental Pharmacology . From: Laboratory Animal Medicine (Third Edition), 2015, Tsutomu M. Kurosawa, ... Chou-Chu Hong, in Laboratory Animals (Second Edition), 2018. AAALAC International publishes position statements that can be used as supplemental guidelines in dealing with issues such as the use of farm animals, occupational health and safety, and adequate veterinary care. In experimental pharmacology and toxicology the aim is to observe for effects induced by chemicals in animals. Different Laboratory Animals And Their Applications In Experimental Pharmacology : Laboratory Animals : These are those animals which can be used and reared (maintain) in the laboratory under suitable conditions. With consideration of the physiology, ecology, and behaviorology of laboratory animals, vehicle sand cages should of suitable size and design to ensure the health and safety of laboratory animals and to prevent their escape. Patrick A. Lester, ... Daniel D. The use of performance standards allows AAALAC International to evaluate each program independently and to provide guidance appropriate to individual situations. In its assessments of animal care and use programs, AAALAC relies on Three Primary Standards: the Guide (NRC 2011a); the Guide for the Care and Use of Agricultural Animals in Research and Teaching (Ag Guide: FASS, 2010); and the European Convention for the Protection of Vertebrate Animals Used for Experimental and Other Scientific Purposes, Council of Europe (ETS 123) 1986. K. Bayne, L.C. Anderson, in Principles of Animal Research for Graduate and Undergraduate Students, 2017. ), the practical steps (experimental conduct, assessment, etc.) Beverly J. Gnadt, in The Laboratory Rat (Second Edition), 2006. An animal model has been developed to study hypertension and atherosclerosis for several reasons. support the lower part of bodyPowerPoint Presentation: rabbit restrained in a lab coat wrapped around the body, and folded under its abdomenRABBIT RESTRAINER: RABBIT RESTRAINEREXPERIMENTAL USES: EXPERIMENTAL USES For pyrogen testing Study of agents affecting capillary permeability Study of antidiabetics and sex hormones Used for experimentation by dermal route Study of teratogens and embryotoxins For research on reproduction BIOMETHODOLOGY OF GUINEA PIG (Cavia porcellus) order- Rodentia: BIOMETHODOLOGY OF GUINEA PIG (Cavia porcellus) order- RodentiaBASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT:MALE 800-200gm ADULT BODY WEIGHT:FEMALE 250-320gm GESTATION PERIOD 65-72days LIFE SPAN 4-5yrs FOOD CONSUMPTION 6gm/100gm/day WATER CONSUMPTION 10ml/100gm/day HEART RATE 230-380beats/min RESPIRATORY RATE 42-104/minPHYSIOLOGICAL DATA: PHYSIOLOGICAL DATA HEART RATE (beats/min) 260-400 RESPIRATORY RATE per min 70-104 TIDAL VOLUME (ml) 1.8 Hb(g/100ml) 8-15 RBC(million/mm 3 ) 5-6 WBC(thousands/mm 3 ) 4-11 BLOOD VOLUME(%B.W) 6-12PowerPoint Presentation: how to hold a guinea pig for treatment HANDLING & RESTRAINT Place the thumb beneath the jaw of guinea pig & support the hindquarter with other handPowerPoint Presentation: EXPERIMENTAL USES Evaluation of bronchodilators Used in immunology Study of local anesthetics Study of vitamin C metabolism Study of TB and INH toxicityBIOMETHODOLOGY OF HAMSTER: BIOMETHODOLOGY OF HAMSTERPowerPoint Presentation: 2 SPECIES syrian/golden (mesocricetus auratus) chinese (cricetulus griseus)BASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT: Syrian 80-90g ADULT BODY WEIGHT: Chinese 35-40g LIFE SPAN 2-3yrsEXPERIMENTAL USES: EXPERIMENTAL USES Research in immunology & virology. The compound blocks beta1 and beta2-adrenoceptors nonselectively. OLAW also has published, and continues to publish, articles on selected PHS Policy provisions in the OPRR Reports (also known as “Dear Colleague” letters), the NIH Guide for Grants and Contracts, Lab Animal, Contemporary Topics in Laboratory Animal Science, and ILAR News. Enter one or more tags separated Based on your opinion, S7A safety pharmacology endpoints in … Animal behavioral and dependence pharmacology. (100 month(s) ago), hi i am suerprise about your well and good presentation, WELCOME: WELCOMEEXPERIMENTAL ANIMALS IN PHARMACOLOGY: EXPERIMENTAL ANIMALS IN PHARMACOLOGY Neena ThomasCONTENTS: CONTENTS INTRODUCTION EXPERIMENTAL ANIMALS HANDLING AND RESTRAINT DRUG ADMINISTRATION BLOOD COLLECTION CONCLUSION REFERENCESINTRODUCTION: INTRODUCTIONEXPERIMENTAL ANIMALS: EXPERIMENTAL ANIMALS Mice Rat Rabbit Guinea pig Hamster Dog Cat Monkey Frog BIOMETHODOLOGY OF MOUSE (mus musculus): BIOMETHODOLOGY OF MOUSE ( mus musculus) Order-RodentiaPowerPoint Presentation: GENERAL BIOLOGY Smaller docile Acute hearing, well developed sense of smell, poor vision & short generation interval circadian rhythm Swiss albino mouse - widely used strainBASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT:MALE 20-40 gm ADULTBODY WEIGHT:FEMALE 18-35 gm LIFE SPAN 1.5-3 yrs FOOD CONSUMPTION 15gm/100gm/day WATER CONSUMPTION 15ml/100gm/day BREEDING ONSET:MALE 50days BREEDING ONSET:FEMALE 50-60days GESTATION PERIOD 19-21days BODY TEMPERATURE 36-37 0 CPHYSIOLOGICAL DATA: PHYSIOLOGICAL DATA HEART RATE (beats/min) 330-780 RESPIRATORY RATE per min 84-230 TIDAL VOLUME (ml) 0.1-0.23 Hb(g/100ml) 10-19 RBC(million/mm 3 ) 4.9-12.5 WBC(thousands/mm 3 ) 4-12 BLOOD VOLUME(%B.W) 7-9HANDLING & RESTRAINT: HANDLING & RESTRAINT GENERAL PRINCIPLES: Use of proper restraint & handling techniques Acclimation period of upto 1 week Handle animals gently & firmly Use restraint devices when appropriate Chemical restraint for prolonged or potentially painful procedures MICE: MICE Grasp the middle of the tail between the thumb & index finger,& lift the mousePowerPoint Presentation: HOW TO PICK UP A MOUSE WITH THUMP FORCEPS Forceps tip covered with rubber/polyethylene tubing Grasp the middle of the tail between the forceps Too much pressure avoidedFOR TREATMENTS & CLOSE EXAMINATIONS : FOR TREATMENTS & CLOSE EXAMINATIONS held by tail & placed on a rough surface Grasp the loose skin over neck & shoulder with the thump & fingersRESTRAINT DEVICES: RESTRAINT DEVICES adapted to the restraint devices regularly monitored access to food or water released from restraint devices at least daily easy to clean & provide adequate ventilationMOUSE RESTRAINER: MOUSE RESTRAINER Different types available Plexiglasses, plastic cones,etc.SEXING: SEXING distance from the anus & genital papilla is greater in malesEXPERIMENTAL USES: EXPERIMENTAL USES Acute toxicity studies Assay of insulin and analgesics in genetics and cancer research Testing of drug for teratogenicity BIOMETHODOLOGY OF RAT (rattus norvegicus) order-Rodentia: BIOMETHODOLOGY OF RAT (rattus norvegicus ) order-RodentiaPowerPoint Presentation: GENERAL BIOLOGY Albino rat - widely used 2 strains: wistar sprague dawleyBASIC BIOLOGIC DATA: BASIC BIOLOGIC DATA ADULT BODY WEIGHT:MALE 300-500 gm ADULT BODY WEIGHT:FEMALE 250-300gm LIFE SPAN 2-3.5 yrs FOOD CONSUMPTION 10gm/100gm/day WATER CONSUMPTION 10-12ml/100gm/day BREEDING ONSET:MALE 65-110days BREEDING ONSET:FEMALE 65-110days GESTATION PERIOD 21-23days BODY TEMPERATURE 38-39 0 CPHYSIOLOGICAL DATA: PHYSIOLOGICAL DATA HEART RATE (beats/min) 300-500 RESPIRATORY RATE per min 65-180 TIDAL VOLUME (ml) 1.5 Hb(g/100ml) 12-17.5 RBC(million/mm 3 ) 7.2-9.6 WBC(thousands/mm 3 ) 6-12 BLOOD VOLUME(%B.W) 6-7HANDLING & RESTRAINT: HANDLING & RESTRAINT Grasp the base of tail wit thumb & forefinger FOR HEAVY RATS FOR SMALL RATSFOR CLOSE TREATMENTS/EXAMINATIONS: FOR CLOSE TREATMENTS/EXAMINATIONS Grasp the whole body with palm over the back & restrain forelimbs. 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